medcelerator · clinician one-pager
First FDA-Approved Treatment for Adults With Recurrent Respiratory Papillomatosis
Papzimeos (zopapogene imadenovec-drba) — four subcutaneous shots over 12 weeks for adults with recurrent respiratory papillomatosis
FDA Approved · United States · September 18, 2026
Condition: Recurrent Respiratory Papillomatosis
Who this is for
This is for adults living with recurrent respiratory papillomatosis who still need repeated airway surgeries and may be candidates for labelled US Papzimeos — four under-the-skin shots over about 12 weeks after surgical debulking — through an ENT / laryngology clinician and Papzimeos SUPPORT. It explains the first FDA-approved RRP therapy, the 12- and 24-month surgery-free results, injection-site and clotting-watch cautions, how to start the prescription conversation, and why authorised is not funded — without treating complete response as a forever cure guarantee, dosing children off-label from this pack, or importing a US vial. Authorized is not funded.
Next clinical step
The US Food and Drug Administration (FDA) has approved this medicine. In the United States, ask your doctor or a specialist whether it suits you. They can write a prescription. Insurance or public drug plan coverage is not guaranteed.
Ways to access this treatment
United States · Prescription
US prescription (FDA-labelled)
https://www.fda.gov/vaccines-blood-biologics/papzimeos
United States · Recruiting clinical trial
Zopa Retreatment and Vector Shedding in Adults With RRP
Tests this treatment. Zopapogene imadenovec in adult RRP, incl. treatment-naive cohort (phase 4).
https://clinicaltrials.gov/study/NCT06538480
See 1 trial on ClinicalTrials.gov: https://clinicaltrials.gov/search?cond=recurrent%20respiratory%20papillomatosis&intr=zopapogene%20imadenovec&aggFilters=status:rec
Possible routes (not confirmed)
United States · Not yet recruiting clinical trial · Applicability unknown
Combination Bevacizumab and PRGN-2012 in Adults With Recurrent Respiratory Papillomatosis (RRP)
Trial not yet recruiting (ClinicalTrials.gov status: not yet taking patients).
https://clinicaltrials.gov/study/NCT07756840
General resources for further research
ClinicalTrials.gov
US National Library of Medicine registry of clinical studies. Search by condition, drug, NCT number, and location. A listing is not enrolment, eligibility, or funding. Talk with the trial contact and a clinician before assuming a slot exists.
https://clinicaltrials.gov/
AI-produced discussion aid; not prescribing instructions. Approval does not establish coverage. Full article: https://medcelerator.com/articles/papzimeos-zopapogene-imadenovec