Twice-Yearly Shot for a Severe Type of Asthma

Who this is for

Next clinical step

Health Canada and the US Food and Drug Administration (FDA) have approved this medicine. In Canada, the United States, the United Kingdom and the European Union, ask your doctor or a specialist whether it suits you. They can write a prescription. Insurance or public drug plan coverage is not guaranteed. In Japan and Australia, authorisation is not confirmed; see Possible routes below if any are listed.

Ways to access this treatment

• United States · Prescription

  US prescription (FDA-labelled)

  https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=30332b20-2ac0-42ad-a775-d3ca7f5fe29f

• Canada · Prescription

  Canada prescription (Health Canada NOC, DIN 02568926/02568934)

  https://health-products.canada.ca/api/drug/drugproduct/?din=02568926

• United Kingdom · Prescription

  UK prescription (MHRA-authorised)

  https://www.gov.uk/government/news/uk-approves-the-first-twice-yearly-biological-medicine-for-asthma-and-severe-chronic-rhinosinusitis-with-nasal-polyps

• European Union · Prescription

  EU prescription (EC marketing authorisation)

  https://www.ema.europa.eu/en/medicines/human/EPAR/exdensur

• United States, United Kingdom, European Union, Canada · Recruiting clinical trial

  Depemokimab Asthma Imaging and Bronchoscopy Sub-Study

  Tests this treatment. Depemokimab in eosinophilic asthma, imaging/bronchoscopy study (phase 3).

  https://clinicaltrials.gov/study/NCT06979323

• United States, United Kingdom · Recruiting clinical trial

  A Study of Efficacy and Safety of Depemokimab Compared With Placebo in Adults and Adolescents With at Risk Type 2 Asthma

  Tests this treatment. Depemokimab vs placebo in asthma, ages 12+ (phase 3).

  https://clinicaltrials.gov/study/NCT07456033

Search all trials on ClinicalTrials.gov: https://clinicaltrials.gov/search?cond=asthma&intr=depemokimab&aggFilters=status:rec

Search Health Canada's Clinical Trials Search Portal: https://clinical-trials-search.canada.ca/en/search?search_api_fulltext=depemokimab

Possible routes (not confirmed)

• Australia · Prescription · Applicability unknown

  Australia prescription (ARTG-registered)

  Australian registration is stated in the article body; the TGA page could not be fetched to confirm it.

General resources for further research

• Canadian Clinical Trial Search Portal (Health Canada)

  Health Canada's public search of the drug and biologic clinical trials it has authorised in Canada (phase 1 to 3, since April 2013). Search by condition, drug, or trial status and see where trials are running. It replaced the Health Canada Clinical Trials Database in July 2026. A listing is not enrolment, and Health Canada does not recruit patients: ask your clinician and contact the trial sponsor.

  https://clinical-trials-search.canada.ca/en/home

• ClinicalTrials.gov

  US National Library of Medicine registry of clinical studies. Search by condition, drug, NCT number, and location. A listing is not enrolment, eligibility, or funding. Talk with the trial contact and a clinician before assuming a slot exists.

  https://clinicaltrials.gov/

• CTIS (EU Clinical Trials Information System)

  European Union public portal for clinical trials submitted under the Clinical Trials Regulation. Search by medicine, condition, and member state. A CTIS record is not an EMA marketing authorisation and is not enrolment.

  https://euclinicaltrials.eu/

• jRCT (Japan Registry of Clinical Trials)

  Japan Registry of Clinical Trials, the public registry used under Japanese clinical-trial rules. Search studies by condition and location. A jRCT listing is not PMDA approval and is not enrolment.

  https://jrct.mhlw.go.jp/en-top